Bio-Rad, AHP3009, CDK10 antibody

Goat anti Human CDK10 antibody recognizes cyclin-dependent kinase 10 (CDK10), also known as serine/threonine-protein kinase PISSLRE. Cyclin-dependent kinases (CDKs) are serine/threonine kinases with activity regulated by specific cyclin partners, and by CDK inhibitors (CKIs). CDKs are well-known for controlling progression through the cell cycle, but also regulate many other cellular processes ( Lim and Kaldis 2013 ). Cyclin M interacts with CDK10, and the CDK10/Cyclin M complex mediates degradation of the oncoprotein and transcription factor ETS2 ( Guen et al. . 2013 ). Loss of CDK10 appears to be a major determinant of resistence to endocrine therapy for breast cancer ( Iorns et al. . 2008 ). In addition, CDK10 seems to act as a tumor suppressor in nasopharyngeal carcicoma and in gastric cancer ( You et al. . 2018 ). Using a zebrafish model, CDK10 was found to participate in transcriptional complexes that play key roles during development ( Guen et al. . 2017 ).

Storage Information
This product is shipped at ambient temperature.
Store at -20°C only.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.