Bio-Rad, AHP3028, BAP1 antibody

Rabbit anti Human BAP1 antibody recognizes BAP1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), also known as BRCA1-associated protein 1 or cerebral protein 6. BAP1 localizes to the nucleus where it acts as a deubiquitinase due to its ubiquitin carboxy-terminal hydrolase (UCH) domain ( Jensen et al . 1998 ). BAP1 is a member of the polycomb-group proteins (PcGs). PcGs are a group of highly conserved transcriptional repressors required for long-term silencing of genes that regulate various processes including cell fate determination, and stem cell pluripotency ( Gaytán de Ayala Alonso et al . 2007 ). BAP1 functions as a tumor suppressor and mutations in the BAP1 gene may be linked to the development of a number of different cancers including malignant mesothelioma ( Cheung and Testa, 2017 ).

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.