Bio-Rad, AHP3032, CDK8 antibody

Rabbit anti Human CDK8 antibody recognizes cell division protein kinase 8, also known as cell division protein kinase 8 or mediator complex subunit CDK8. CDK8 is a 53 kDa is a member of the cyclin-dependent protein kinase (CDK) family involved in transcriptional regulation via interaction with the mediator complex ( Tassan et al . 1995 ). CDK8 regulates the activity of several transcription factors via its kinase activity, including STAT1 ( Bancerek et al . 2013 ). CDK8 is also able to inhibit transcriptional activation by influencing the turnover of subunits in the mediator complex tail module and mediating the binding of RNA polymerase II to the mediator complex ( Tsai et al . 2013 ). Expression of CDK8 may contribute to the development of a number of different types of cancer ( Firestein et al . 2008 , Donner et al . 2007 ).

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.