Bio-Rad, AHP377, Dynorphin B antibody

Rabbit anti Dynorphin B antibody recognizes dynorphin B, an endogenous opioid peptide, also known as rimorphin with the peptide sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr, (YGGFLRRQFKVVT) derived from the sequential cleavage of pro-enkephalin B to form leumorphin which is, in turn cleaved to form dynorphin B ( Devi et al. 1985 ). The cleavage of the dynorphin precursors to form the dynorphin neuropeptides is largely controlled by the serine protease cathepsin L which co-localizes with dynorphins in secretory vesicles of brain cortical neurons ( Funkelstein et al. 2010 ) and prohormone convertase 2 , a member of the furin, peptidate S8 family ( Schwarzer 2009 ). Dynorphin b sequence is well conserved among mammal, avian ( Youngren et al. 1993 ) and reptilian ( Goldsmith et al. 1992 ) species. Rabbit anti Dynorphin b antibody is expected to have a wide species cross reactivity.

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.