Bio-Rad, HCA383, Dupilumab antibody | AbD47090ia
Size: 0.1 mg, Human anti Dupilumab
Catalog Number: HCA383
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Pack Size0.1 mg
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| Product Form | Human IgG1 antibody (lambda light chain) selected from the HuCAL phage display library and expressed in a human cell line. This product is supplied as a liquid. |
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| Preservative Stabilisers | 0.09% Sodium Azide (NaN 3 ) |
| Immunogen | Dupilumab |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| Product Type | Monoclonal Antibody |
| Clone | AbD47090ia |
| Isotype | IgG1 |
| Specificity | Dupilumab |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A |
| Buffer Solution | Phosphate buffered saline |
| Approx. Protein Concentrations | Antibody concentration 0.5 mg/ml |
| Source | HKB-11 |
| Synonyms | Dupixent |
| Affinity | The intrinsic affinity of the monovalent form of Human anti Dupilumab antibody, clone AbD47090ia is K D = 0.4 nM as measured by real time, label free molecular interaction analysis on immobilized Dupilumab. |
| Acknowledgements |
Answer:Yes. It selectively recognizes free dupilumab through an inhibitory anti-idiotypic interaction.
Answer:No. Free IL-4Rα and receptor-bound dupilumab are not the intended analytes.
Answer:Purified human IgG1 monoclonal antibody, 0.1 mg.
Human Anti-Dupilumab Antibody clone AbD47090ia is an inhibitory, paratope-specific anti-idiotypic monoclonal antibody for therapeutic drug immunoassay development. Its IgG1 structure recognizes free dupilumab but not free interleukin-4 receptor alpha or dupilumab already complexed with that receptor. This selectivity makes the reagent useful for preparing surrogate anti-drug antibody positive controls and calibrators in immune-response assay studies. A typical bridging ELISA uses dupilumab as the capture and detection ligand, with the anti-dupilumab antibody serving as an assay-positive reference. Evaluate possible sample-matrix interference with human serum dilutions and include negative human immunoglobulin controls during method qualification. The antibody is a purified recombinant human IgG1 supplied in a liquid phosphate-buffered formulation; it is not itself the therapeutic drug. Use experimental concentration ranges established for the intended assay rather than assuming a universal dilution. The provided pack contains 0.1 mg and is for research use.
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| This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details. Dupixent is a trademark of Regeneron Pharmaceuticals, Sanofi-Aventis. |
| Licensed Use | For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad. |
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