Bio-Rad, HCA392, Belatacept antibody | AbD37060ia

Human Anti-Belatacept Antibody, clone AbD37060ia is an affinity-matured, inhibitory, anti-idiotypic antibody. It recognizes the drugs belatacept and abatacept, and their biosimilar products as well as cytotoxic T-lymphocyte antigen-4 (CTLA-4), also known as CD152. Clone AbD37060ia is a monoclonal antibody with hIgG1 isotype and is suitable as a positive control or as a calibrator for the set-up of an anti-drug antibody (ADA) assay. This clone is also available in a Fab format ( HCA391 ) This Anti-Belatacept Antibody cross-reacts with the drug abatacept (Orencia). It is only 2 amino acids different from abatacept. LEA29Y-belatacept was constructed by two amino acid substitutions (L104E and A29Y) compared to abatacept that gave rise to slower dissociation rates for both CD86 and CD80. Belatacept (Nulojix) is a genetically engineered fusion protein which consists of the functional binding domain of modified human CTLA-4 and the Fc domain of human monoclonal immunoglobulin of the IgG1 subclass. The Fc part has the allotype IGHG1*05. Belatacept is indicated for prophylaxis of organ rejection in adult patients receiving a kidney transplant. It is to be used in combination with basiliximab induction, mycophenolate mofetil, and corticosteroids. View a summary of all anti-belatacept antibodies

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.