Bio-Rad, HCA431, Belimumab antibody | AbD60132ia

Human Anti-Belimumab Antibody, clone AbD60132ia is a paratope specific, inhibitory, anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody drug belimumab, and its biosimilar products. It does not recognize the drug target, the B-cell activating factor BAFF (CD257), nor belimumab in complex with BAFF. HCA431 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 0.2nM for belimumab and is one of the three antibodies offered for ADA assays. Antibody HCA429 has an affinity of 16nM and HCA430 has an affinity of 3nM for belimumab. Belimumab (trade name Benlysta) is a fully human monoclonal antibody of the IgG1/lambda isotype that binds to the B-cell activating factor BAFF to prevent its binding to B cells. Although part of the normal immune system, B cells are also responsible for the over-aggressive immune response observed in autoimmune diseases, such as systemic lupus erythematosus (SLE). Through its binding to BAFF, belimumab makes BAFF unavailable to B cells, which induces B cells apoptosis and therefore, a reduction in the overall number of circulating B cells. Therefore, belimumab acts as an immunosuppressant drug and is approved for the treatment of systemic lupus erythematosus. View a summary of all anti-belimumab antibodies

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.