Bio-Rad, TZA011, Atezolizumab antibody | AbD40638ad

Human Anti-Atezolizumab Antibody, clone AbD40638ad is a paratope specific, inhibitory anti-idiotypic antibody (Type 1) that specifically recognizes the free monoclonal antibody drug atezolizumab. It does not recognize the drug target, Programmed Cell Death Ligand 1 (PD-L1), nor atezolizumab in complex with PD-L1. The antibody can be used to measure levels of free atezolizumab in patient samples. The antibody is tagged with a SpyTag2 at the C-terminus of the Fab antibody heavy chain, enabling the user to couple it to a SpyCatcher reagent for conversion to alternative formats in less than one hour. View a summary of all SpyCatcher products A pair of anti-atezolizumab antibodies can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. This antibody, in monovalent Fab format, is recommended as the capture antibody, together with clone AbD40992ia ( HCA381 ) as the detection antibody. Clone AbD40638ad is also available in full length IgG1 format under product code HCA382 . Atezolizumab (Tecentriq) is a human monoclonal IgG1 antibody that binds directly to Programmed Cell Death Ligand 1 (PD-L1, CD274) and provides a dual blockade of both the PD-1 and B7.1 receptors on T-cells and antigen presenting cells. It is one of the named “checkpoint inhibitor” drugs. PD-L1/PD-1 mediated inhibition of the immune response is thereby released, including reactivation of the anti-tumour immune response without induction of antibody-dependent cellular cytotoxicity. The drug is used to treat urothelial carcinoma, non-small cell lung cancer, triple-negative breast cancer, small cell lung cancer and hepatocellular carcinoma. It is used either on its own or in combination for cancers which are advanced or metastatic. View a summary of all anti-atezolizumab antibodies

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.