Bio-Rad, VMA00931, ARF1 antibody | E01/8D1

Mouse anti ARF1 antibody recognizes ADP-ribosylation factor 1. ARF1 is a small GTPase which cycles between an inactive, GDP-bound state and an active, GTP-bound state. When active, ARF1 can tightly bind effectors and this binding results in biological function ( Beck et al. 2008 ). ARF1 is involved with membrane traffic at the Golgi, including vesicle budding and podocyte function ( Rafiq et al. 2017 ). Roles of ARF1 have also been identified in connectivity of mitochondrial networks and mitophagy ( Ackema et al. 2014 ). Overexpression of ARF1 stimulates tumor progression and invasion, and therefore, blocking its activation has been suggested as a way to inhibit cancer progression ( Prieto-Dominguez et al. 2019 ), and also to enhance the effectiveness of chemotherapy ( Xu et al. 2017 ).

Storage Information
This product is shipped at ambient temperature.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles