Description
Description
Pultrix™ XQ membrane adsorber is an innovative strong anion exchange ligand based on membrane technology. It utilizes a crosslinked polymer coating functionalized with high-density quaternary ammonium (Q) groups to facilitate the capture and purification of negatively charged biomolecules.
Pultrix™ XQ membrane adsorber features a highly interconnected membrane structure (2 μm nominal pore size) and a high density of quaternary ammonium ligands, delivering a large surface area and excellent accessibility for the capture of DNA, proteins, and other large biomolecules. Its open-channel design enables convective flow, ensuring rapid and efficient binding of target molecules. Compared to traditional chromatography resins, XQ membranes support significantly higher flow rate and offer superior dynamic binding capacity for large entities such as host cell DNA, plasmid DNA, host cell proteins, and enveloped viruses — reducing process time and achieve cost reduction effect.
Features
High Binding Efficiency: Based on convective mass transfer, charged biomolecules are captured in a single pass through the membrane adsorber, without relying on retention time.
High Flow Rates: 10 MV/min within pressure limits by using membrane adsorbers increases productivity by 30-50 times compared to traditional packed-bed chromatography.
Linear Scalability and Flexibility: A full range of membrane adsorber, from process development to production scale.
Cost-effective: Compared to conventional column, it can significantly reduce overall costs at both the IND and commercial stages.
Easy to Use: Only a simple connection for immediate use.
Applications
Plasmid capture from lysate (integrated lysate concentration/buffer exchange, size exclusion, and anion exchange – as in traditional plasmid purification)
Purification of biological fluids through the removal of host-derived DNA, viruses, host cell proteins (HCPs), and endotoxins
Designed for the capture large biomolecular targets such as recombinant proteins, plasmids, viral vectors, and plasma constituents
Quality Standards
ISO 9001: 2015 Quality Management System
Manufactured for use in conformance with cGMP
Each product is integrity tested prior to release
COA/COQ provided with shipment
Validation documents are available upon request
