Description
Description
By offering various lengths, membrane filtration areas, and module diameters, Cobetter hollow fiber modules can facilitate a smooth and predictable scale-up from laboratory to pilot-scale and eventually manufacturing-scale. Available from Mini, Minilab, Lab, Pilot, Pilot+, Process and Max.
Cobetter hollow fiber modules are made of modified polyethersulfone membranes(m-PES), which have high flow flux and low protein binding. They are easy to install, clean and sanitize, and are widely used in cell harvest, clarification, perfusion, diafiltration and concentration in upstream and downstream bioprocessing.
Compared with TFF Cassettes ' tortuous and complicated flow path, hollow fiber filtration has a linear flow path which creates a smooth flow for more gentle separation.
Effective Length and Scale-Up
The process scale-up feature of hollow fibers is that direct process scale-up can be carried out as long as the effective length is kept the same.
On the contrary, due to the significant pressure drop difference between inlet and outlet that exists in different lengths, the internal pressure and flow velocity distribution of the flow channel also change correspondingly, so linear scale-up can not be performed on devices with different lengths. When processing with more fouling and high viscosity products, it is preferred to choose a module with shorter length.
Features
High flux rates, high filtration capacity
Modified hydrophilic PES hollow fiber membrane provides low protein binding, less membrane fouling and easy cleaning
Integrated device without additional assembly or device holder, quick installation and operation
Re-washed with 0.5M NaOH solution
Simple and reliable linear scale-up
Applications
Purification, concentration and diafiltration of vaccine
Purification, concentration and diafiltration of viral vector
Clarification of cells and bacteria in fermentation broth
Recycling and washing of cells and bacteria
Concentration and diafiltration of protein
Quality Standards
ISO 9001: 2015 Quality Management System
Manufactured for use in conformance with cGMP
Each product is integrity tested prior to release
COA/COQ provided with shipment
Validation documents are available upon request
TSE/BSE certificate available
