Cobetter, HFEPR500R1011AP, Biophsep™ Process Hollow Fiber Filter mPES Membrane, Autoclavable

Description
By offering various lengths, membrane filtration areas, and module diameters, Cobetter hollow fiber modules can facilitate a smooth and predictable scale-up from laboratory to pilot-scale and eventually manufacturing-scale. Available from Mini, Minilab, Lab, Pilot, Pilot+, Process and Max.
Cobetter hollow fiber modules are made of modified polyethersulfone membranes(m-PES), which have high flow flux and low protein binding. They are easy to install, clean and sanitize, and are widely used in cell harvest, clarification, perfusion, diafiltration and concentration in upstream and downstream bioprocessing.
Compared with TFF Cassettes ' tortuous and complicated flow path, hollow fiber filtration has a linear flow path which creates a smooth flow for more gentle separation.
Effective Length and Scale-Up
The process scale-up feature of hollow fibers is that direct process scale-up can be carried out as long as the effective length is kept the same.
On the contrary, due to the significant pressure drop difference between inlet and outlet that exists in different lengths, the internal pressure and flow velocity distribution of the flow channel also change correspondingly, so linear scale-up can not be performed on devices with different lengths. When processing with more fouling and high viscosity products, it is preferred to choose a module with shorter length.
Features
Aseptic Process Assurance: For processes where bioburden cannot be sufficiently reduced using a 0.2 μm sterilizing-grade filter, heat sterilization hollow fiber filter can ensure aseptic operation
Reusable Design: The membranes can be cleaned and reused for multiple times, reducing overall operating costs
High Temperature and Pressure Resistance: Supports steam-in-place or autoclave
Applications
Yeast, oncolytic bacteria, and other cell harvesting/purification
Polycystic liposome concentration and diafiltration
Continuous cell perfusion culture
Aseptic concentration of lentivirus and adenovirus vaccines
Aseptic purification of monoclonal antibodies and recombinant proteins
Quality Standards
ISO 9001: 2015 Quality Management System
Manufactured for use in conformance with cGMP
Each product is integrity tested prior to release
COA/COQ provided with shipment
Validation documents are available upon request
TSE/BSE certificate available