Description
Product Usage Information
Mitochondrial Fusion Promoter M1 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.92 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles .
Background
Mitochondrial Fusion Promoter M1 is a hydrazone compound that promotes mitochondrial fusion in fragmented mitochondria (1). In a study of human induced pluripotent stem cells (iPSCs), M1 fused fragmented mitochondria and promoted the differentiation of iPSCs into an early mesodermal cardiac lineage (2). Pancreatic β cells treated with soluble cholesterol triggers increased total cholesterol accumulation, diminished cellular respiration, and compromised glucose-stimulated insulin secretion. Treatment of these cells with M1 prevents cholesterol-mediated suppression of cellular respiration and increases glucose-stimulated insulin secretion (3). M1 is also seen to protect against brain damage in rats with induced cardiac ischemia/reperfusion (I/R) injury (4) and against diabetic cardiomyopathy in a rat model of diabetes (5). Treatment of donor microvascular endothelial cells with M1 and the fission inhibitor Mdivi1 promotes mitochondrial fusion and reduces recipient T cell responses, which may lead to improved cardiac transplant survival (6).
Alternate Names
(E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol; 1-(5-Chloro-2- hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
