CST, 88058S, Tigecycline

Product Usage Information
Tigecycline is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 10 mg of powder in 1.13 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Background
Tigecycline, also known as GAR-936, is a broad spectrum glycylcycline antimicrobial that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA. This prevents protein synthesis and limits bacterial growth. Tigecycline has a 9- -butyl-glycylamido side chain on the central skeleton, giving it the ability to overcome most tetracycline resistance mechanisms (1). studies have shown that Tigecycline has activity against multidrug-resistant Gram-negative and -positive bacteria, vancomycin-resistant enterococci (VRE), methicillin-resistant (MRSA) and (MRSE), and penicillin-resistant (1,2). Studies have also found that Tigecycline can selectively kill human leukemia stem and progenitor cells with no disruption to normal hematopoietic cells (3). This small compound has been shown to induce apoptosis and inhibit cell proliferation in cervical cancers by suppressing the Wnt/β-catenin signaling pathway (4).
Alternate Names
9-t-Butylglycylamidominocycline; GAR-936; GAR936