Lonza, N190, β-G-Blocker

Name: β-G-Blocker
Brand: Lonza
SKU: N190

β-G-Blocker, 5 × 5 mL

Catalog Number: N190

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Category

Endotoxin Detection Reagents

Pack Size5 ML / vial

TagsEndotoxin Detection

Description

Product Overview ß-1,3-Glucans can produce false positive results in LAL assays. Some examples of glucan sources include yeast and cellulosic materials including hemodialysis filters. Our ß-G-Blocker may be used with any of our LAL assays. Note: PYROGENT® Gel Clot LAL products typically do not require ß-G-Blocker. UPDATE (July 2018): Historically this product has been filled in a 5cc screw neck vial and sealed with a black screw cap. A change is being made to update the vial configuration to a 5cc vial which is stoppered and crimped, similar to Lonza's other endotoxin detection products. This change will enable us to automate the filling process, which will increase product quality and throughput. The implementation date for this change was July 2018. Following ICH guidelines, three lots of product were placed on real-time and accelerated stability. Aseptic media simulations were executed to qualify the change in container closure components and the automated filler. Product in the new container has passed all stability time points required for product release. As the full stability protocol has not been completed, the expiry of the product will be reduced to 12 months. Lonza will reevaluate the product expiration as additional stability data is obtained. Request More Info
Storage and Content 5 mL/vial

FAQs

Question: What interference does β-G-Blocker address?

Answer:It reduces β-1,3-glucan interference that can cause false-positive LAL responses.

Question: How is the product packaged?

Answer:The product contains five 5 mL vials.

Question: Can it be used with LAL assays?

Answer:Yes. It is intended as an accessory reagent when glucan interference must be controlled during LAL testing.

Application Note

β-G-Blocker is an accessory reagent for Limulus Amebocyte Lysate testing when β-1,3-glucans could cause non-endotoxin activation and false-positive assay results. This configuration contains five 5 mL vials. Potential glucan sources include yeast-derived materials and cellulosic products such as some filtration media. The blocker can be used with Lonza LAL assays when glucan interference needs to be reduced so the test response more specifically reflects bacterial endotoxin. It is particularly useful during method development or sample-interference investigations where a positive result may be caused by glucan-sensitive pathways rather than endotoxin. Standard PYROGENT gel-clot products generally do not require the blocker for routine samples, so use is selected based on matrix characteristics and assay validation.

Ordering

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