Merck, 196000-10UG, Bafilomycin A1, Streptomyces griseus

Name: Bafilomycin A1, Streptomyces griseus
Brand: Merck
SKU: 196000-10UG

Size:10 μg, Bafilomycin A1, Streptomyces griseus

Available Catalog Numbers

196000-10UG 196000-1SET

Catalog Number: 196000-10UG

Pricing

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Category

Phosphatase Inhibitors

Pack Size10 µg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP).
Note: 1 set = 3 x 10 µg
Biochem/physiol Actions
Primary Target
vacuolar type H⁺ ATPase
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.
Other Notes
Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.
Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem.270, 7272.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun.269, 255.
Crider, B.P., et al. 1994. J. Biol. Chem.269, 17379.
Palokangas, H., et al. 1994. J. Biol. Chem.269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res.9, 1575.
Drose, S., et al. 1993. Biochemistry32, 3902.
Furuchi, T., et al. 1993. J. Biol. Chem.268, 27345.
Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA85, 7972.
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
Web Name Override	Bafilomycin A1
MDL number	MFCD06795130
Web Name Suffix Override	from Streptomyces griseus, ≥90% (HPLC), film, V-ATPase inhibitor
SMILES string	O1[C@@H]([C@H]([C@@H](C[C@]1(O)[C@H]([C@H](O)[C@@H]([C@H]2OC(=O)\C(=C\C(=C\[C@H]([C@H]([C@H](C\C(=C\C=C\[C@@H]2OC)\C)C)O)C)\C)\OC)C)C)O)C)C(C)C
InChI	1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChI key	XDHNQDDQEHDUTM-JQWOJBOSSA-N
assay	≥90% (HPLC)
form	film
shelf life	3 yr
storage condition	OK to freeze
solubility	DMSO: 100 μM
storage temp.	−20°C
Quality Level	100

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