Merck, 203325, BMS

Name: BMS
Brand: Merck
SKU: 203325

Size:, BMS, bis(2-Mercaptoethylsulfone), Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT.

Catalog Number: 203325

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Category

Chelating Agents

TagsChemistry & Biochemicals Biochemicals Chelating & Reducing Agents

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at pH 7 with BMS than with DTT. Has a pKa of 7.9 and 9.0.
Packaging
Packaged under inert gas
Preparation Note
May require warming (40-45°C) to achieve complete solubilization in H₂O.
Other Notes
Singh, R., et al. 1995. Methods Enzymol.251, 167.
Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem.22, 109.
Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem.58, 633.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)

Specifications

General

Composition	Mixture
Quantity	50 Pk.
Volume (Metric)	5 g/Tablet
Sterility	Sterile
pH	2.5 to 3.0 (aq. soln.)
Unit Size	Each

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