Merck, 700017P-10MG, 25-hydroxycholesterol-3-sulfate

Name: 25-hydroxycholesterol-3-sulfate
Brand: Merck
SKU: 700017P-10MG

Size:10 mg, 5-cholesten-3beta, 25-diol 3-sulfate; 25HC3S, Avanti Research™ - A Croda Brand

Available Catalog Numbers

700017P-10MG 700017P-5MG

Catalog Number: 700017P-10MG

Pricing

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Category

Dry Ice

Pack Size10 mg

TagsChemistry & Biochemicals Biochemicals Avanti Research™A Croda Brand

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
25-hydroxycholesterol-3-sulfate (25OHC3S) is a nuclear oxysterol. It accumulates in hepatocyte nuclei upon steroidogenic acute regulatory protein (STARD1) overexpression.
Application
25-hydroxycholesterol-3-sulfate has been used to induce anti-inflammatory responses and understand its effect on lymphocyte migration. It has also been used as an oxysterol sulfate standard in mass spectroscopy and liquid chromatography methods.
Biochem/physiol Actions
25-hydroxycholesterol-3-sulfate (25OHC3S) is involved in lipid homeostasis in liver and is a lipid metabolism regulator. 25OHC3S acts on liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) and inhibits cholesterol synthesis by downregulating enzymes of the biosynthesis pathway in hepatocytes and macrophages. It also acts an agonist for peroxisome proliferator-activated receptor γ (PPAR-γ) and modulates the nuclear factor κ-light-chain-enhancer (NF-κB) based inflammatory response. 25OHC3S modulates tumor necrosis factor α (TNFα)-induced inflammatory response in hepatocytes.
Packaging
5 mL Amber Glass Screw Cap Vial (700017P-10mg)
5 mL Amber Glass Screw Cap Vial (700017P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC

Specifications

General

MDL number	MFCD28143668
UNSPSC Code	12352211
NACRES	NA.25
InChI key	OEGAOHNRCSZIRO-KSGNISEOSA-M
SMILES string	[H][C@@]12[C@]([C@](CC[C@H](OS(=O)([O-])=O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)(O)C.[Na+]
description	25-hydroxycholesterol-3-sulfate (sodium salt)
assay	>99% (TLC)
form	powder
packaging	pkg of 1 × 10 mg (700017P-10mg)
manufacturer/tradename	Avanti Research™ - A Croda Brand
shipped in	dry ice
storage temp.	−20°C

Ordering

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