Merck, 860493P-10MG, 1-deoxysphinganine

Name: 1-deoxysphinganine
Brand: Merck
SKU: 860493P-10MG

Size:10 mg, 1-deoxysphinganine (m18:0), Avanti Research™ - A Croda Brand 860493P, powder

Available Catalog Numbers

860493P-10MG 860493P-1MG

Catalog Number: 860493P-10MG

Pricing

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Category

Dry Ice

Pack Size10 mg

TagsChemistry & Biochemicals Biochemicals Avanti Research™A Croda Brand

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
1-deoxysphinganine is synthesized by the condensation of palmitic acid with alanine or glycine in the presence of enzyme serine palmitoyltransferase (SPT). It is metabolized to 1-deoxyceramides.
Application
1-deoxysphinganine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line. It is also suitable for use as a neurotoxic agent in human CD8⁺ T cells.
Biochem/physiol Actions
1-deoxysphinganine elicits cytotoxicity towards dorsal root ganglion (DRG) neurons by disrupting the neuronal cytoskeleton formation. High levels of 1-deoxysphinganine in diabetic patients may contribute to the reduction of pancreatic β cell functionality. In hereditary sensory and autonomic neuropathy type I, mutation in the serine palmitoyltransferase gene results in altered substrate specificity, resulting in the accumulation of 1-deoxysphinganine.
Packaging
5 mL Amber Glass Screw Cap Vial (860493P-10mg)
5 mL Amber Glass Screw Cap Vial (860493P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC

Specifications

General

MDL number	MFCD22416644
UNSPSC Code	12352211
NACRES	NA.25
Web Name Suffix Override	Avanti Research™ - A Croda Brand
SMILES string	C[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC
InChI	1S/C18H39NO/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17(2)19/h17-18,20H,3-16,19H2,1-2H3/t17-,18+/m0/s1
InChI key	YRYJJIXWWQLGGV-ZWKOTPCHSA-N
assay	>99% (TLC)
form	powder
packaging	pkg of 1 × 1 mg (860493P-1mg)
manufacturer/tradename	Avanti Research™ - A Croda Brand 860493P
lipid type	bioactive lipidssphingolipids
shipped in	dry ice
storage temp.	−20°C

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