Merck, A1895-25G, Aurintricarboxylic acid

Name: Aurintricarboxylic acid
Brand: Merck
SKU: A1895-25G

Size:25 g, ATA, practical grade, ≥85% (titration), powder

Available Catalog Numbers

A1895-25G A1895-5G

Catalog Number: A1895-25G

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Category

Special Stains

Pack Size25 g

TagsClinical & Diagnostics Tissue Diagnostics Hematology Stains

CollectionsMerck Tissue Diagnostics – Universal Reagents for Histology & IHC Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum.
It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase).
It has been used as a ribonuclease inhibitor.

Biochem/physiol Actions
Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca²⁺ -impermeable GluR2 receptors and inhibits calpain, a Ca²⁺-activated protease that is activated during apoptosis.

Specifications

General

NACRES	NA.47
PubChem Substance ID	24278210
UNSPSC Code	12171500
Web Name Suffix Override	≥85% purity (titration), practical grade, powder
EC Number	224-628-1
MDL number	MFCD00011663
InChI key	GIXWDMTZECRIJT-UHFFFAOYSA-N
InChI	1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
SMILES string	OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O
grade	practical grade
assay	≥85% (titration)
form	powder
technique(s)	titration: suitable
color	red to very dark red, and Red-Brown andBrown-Red
mp	300 °C (lit.)
solubility	1 M NH4OH: 10 mg/mL
application(s)	diagnostic assay manufacturinghematologyhistology
storage temp.	room temp
Quality Level	300

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