Merck, A3411-25MG, Aminopterin

Name: Aminopterin
Brand: Merck
SKU: A3411-25MG

Size:25 mg, (S)-2-{4-[(2, 4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid, 4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid, powder, BioReagent, suitable for cell culture

Available Catalog Numbers

A3411-100MG A3411-10MG A3411-25MG

Catalog Number: A3411-25MG

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Category

Hormones for Cell Culture

Pack Size25 mg

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Supplements for Cell Culture

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Aminopterin has been used in the production of anti- neurogranin antibodies.
Biochem/physiol Actions
Aminopterin is found to inhibit growth, embryogenesis and has toxic effects in mice models. It serves as a abortifacient. Aminopterin is known to reduce the effects of acute leukemia in children.
Folic acid antagonist that binds to dihydrofolate reductase and inhibits its activity.
Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.
Other Notes
More potent, but more toxic, than methotrexate.

Specifications

General

PubChem Substance ID	24890768
UNSPSC Code	12352205
MDL number	MFCD00036692
NACRES	NA.75
EC Number	200-209-9
Beilstein/REAXYS Number	69045
InChI key	TVZGACDUOSZQKY-LBPRGKRZSA-N
InChI	1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1
SMILES string	Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
biological source	synthetic (organic)
product line	BioReagent
assay	≥97%
form	powder
technique(s)	cell culture \| mammalian: suitable
color	yellow
solubility	2 M NaOH: 50 mg/mL
ε (extinction coefficient)	24,500 at 282 nm in 0.1 M NaOH at 1 M
web metadata keyword.default	Sigma-Aldrich A3411, Aminopterin powder, BioReagent, suitable for cell culture, 4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid, folic acid analogue, DHFR inhibitor, antifolate, hybridoma selection agent

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