Merck, D7385-10MG, Demecolcine

Name: Demecolcine
Brand: Merck
SKU: D7385-10MG

Size:10 mg, N-Deacetyl-N-methylcolchicine, ≥98% (HPLC)

Available Catalog Numbers

D7385-10MG D7385-50MG D7385-5MG

Catalog Number: D7385-10MG

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Category

Special Stains

Pack Size10 mg

TagsClinical & Diagnostics Tissue Diagnostics Hematology Stains

CollectionsMerck Tissue Diagnostics – Universal Reagents for Histology & IHC Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Demecolcine has been used as a microtubule depolymerizing agent. It has also been used to inhibit mitotic division.
Biochem/physiol Actions
Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G₁ and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.

Specifications

General

UNSPSC Code	12171500
NACRES	NA.47
PubChem Substance ID	24894128
EC Number	207-514-6
Beilstein/REAXYS Number	2822892
MDL number	MFCD00075459
InChI key	NNJPGOLRFBJNIW-HNNXBMFYSA-N
InChI	1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
SMILES string	CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13
assay	≥98% (HPLC)
form	powder
mp	184 °C
solubility	chloroform: 10 mg/mL
application(s)	diagnostic assay manufacturinghematologyhistology
storage temp.	2-8°C
Quality Level	200

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