Merck, D9160-10MG, 1-Deoxymannojirimycin hydrochloride

Name: 1-Deoxymannojirimycin hydrochloride
Brand: Merck
SKU: D9160-10MG

Size:10 mg, 1-Deoxymannojirimycin HCl, 1, 5-Dideoxy-1, 5-imino-D-mannitol hydrochloride

Available Catalog Numbers

D9160-10MG D9160-5MG

Catalog Number: D9160-10MG

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Category

Antibiotics & Antimycotics

Pack Size10 mg

TagsChemistry & Biochemicals Biochemicals Antibiotics

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Chemical structure: glucosamine
Application
1-Deoxymannojirimycin (DMM) hydrochloride is an inhibitor of N-linked glycosylation and has antiviral activity. Derivatives of deoxymannojirimycin may have anti-HIV activity. It has been used for treatment of T lymphocytes and to study it′s effect on allogeneic cytotoxic T lymphocytes (CTL). It is used for studies on Golgi-mediated glycoprotein processing.
Biochem/physiol Actions
1-Deoxymannojirimycin is a mannosidase I inhibitor, alters cell-surface complex carbohydrate structure as assayed by PHA-L binding, and increases high mannose structures as indicated by the increased Con-A binding.
Selectively inhibits Golgi associated α(1→2) mannosidase and for studies on Golgi-mediated glycoprotein processing.

Specifications

General

NACRES	NA.76
PubChem Substance ID	24894265
UNSPSC Code	51102829
MDL number	MFCD00083611
InChI key	ZJIHMALTJRDNQI-MVNLRXSJSA-N
SMILES string	Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
InChI	1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1
form	powder
color	white to off-white
solubility	H2O: 10 mg/mL
antibiotic activity spectrum	viruses
mode of action	enzyme \| inhibits
storage temp.	2-8°C
Quality Level	200

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