Merck, D9305-10MG, 1-Deoxynojirimycin hydrochloride

Name: 1-Deoxynojirimycin hydrochloride
Brand: Merck
SKU: D9305-10MG

Size:10 mg, 1, 5-Dideoxy-1, 5-imino-D-sorbitol hydrochloride

Available Catalog Numbers

D9305-10MG D9305-5MG

Catalog Number: D9305-10MG

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Category

Antibiotics & Antimycotics

Pack Size10 mg

TagsChemistry & Biochemicals Biochemicals Antibiotics

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Chemical structure: glucosamine
Application
1-Deoxynojirimycin hydrochloride has been used
to study its effects on the loss-of-function of N-glycosylation pathway on hair cell regeneration
as an endoplasmic reticulum (ER) α-glucosidase I and II inhibitor to study its effects on TMED3-cystic fibrosis transmembrane conductance regulator (CFTR) interaction
as an insect trehalase inhibitor in TREH inhibition bioassay

Biochem/physiol Actions
α-Glucosidase inhibitor
1-Deoxynojirimycin (DNJ) is a naturally occurring alkaloid azasugar or iminosugar. It is observed in mulberry leaves, Commelina communis, and bacterial strains including Bacillus and Streptomyces species. DNJ acts as an α-glucosidase inhibitor and exhibits anti-viral anti-diabetic, anti-inflammatory, anti-obesity, and antioxidant properties.

Specifications

General

UNSPSC Code	12352201
NACRES	NA.32
PubChem Substance ID	24278397
MDL number	MFCD00133247
Beilstein/REAXYS Number	3563225
InChI	1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/m1./s1
SMILES string	Cl[H].OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
InChI key	ZJIHMALTJRDNQI-VFQQELCFSA-N
assay	≥98% (TLC)
form	powder
solubility	water: 19.60-20.40 mg/mL, clear, colorless
antibiotic activity spectrum	viruses
mode of action	enzyme \| inhibits
storage temp.	2-8°C
Quality Level	200
Gene Information	human ... GAA(2548)

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