Description
General description
Neurogranin plays a pivotal role in learning and memory by modulating synaptic plasticity. TREM2, expressed on microglia, governs immune responses and facilitates amyloid clearance. ApoE4, a major genetic risk factor for Alzheimer′s, influences lipid metabolism and neuronal repair. FABP3 marks neuronal damage, while ferritin and angiogenin reflect neuroinflammatory activity and vascular health—together painting a multifaceted picture of brain dysfunction.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 analytes in human serum, plasma, and cerebrospinal fluid (CSF).
Analytes included: Angiogenin, Apolipoprotein E4 (ApoE4), Fatty Acid Binding Protein 3 (FABP3), Ferritin, Neurogranin, Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
Note: When testing serum/plasma samples, Angiogenin and ApoE4 require a 1:200 dilution while FABP3, Ferritin, Neurogranin and TREM2 require a 1:10 dilution. These sets of analytes should not be multiplexed together and instead run as separate assays. If testing CSF samples, all analytes can be plexed together.
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Features and Benefits
Comprehensive Pathway Coverage: Simultaneously quantify six critical neurological biomarkers spanning synaptic function, neuroinflammation, and lipid metabolism, providing a complete picture of neurodegeneration in a single assay.
Dual-Fluid Versatility: Analyze both challenging CSF samples and accessible blood samples with exceptional sensitivity, enabling flexible study designs while addressing the critical need for blood-based neurological biomarkers.
Research-Ready Reliability: Trust in consistent, reproducible results with
Streamlined Neuroscience Workflow: Eliminate the complexity of multiple single-analyte assays with our comprehensive 6-plex format, accelerating your research timeline and maximizing your sample utility for breakthrough neurological insights.
Legal Information
Luminex is a registered trademark of Luminex Corporation
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
