Merck, M6133-10MG, 7-Methylguanosine 5′-triphosphate sodium salt

Name: 7-Methylguanosine 5′-triphosphate sodium salt
Brand: Merck
SKU: M6133-10MG

Size:10 mg, m7GTP, ≥85% (HPLC)

Available Catalog Numbers

M6133-10MG M6133-25MG M6133-5MG

Catalog Number: M6133-10MG

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Category

Nucleotides & Nucleosides

Pack Size10 mg

TagsChemistry & Biochemicals Biochemicals Nucleosides & Nucleotides

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
7-Methylguanosine 5′-triphosphate is a mRNA cap structural analog.
Application
7-Methylguanosine 5′-triphosphate sodium salt has been used to test its affinity towards Poly(A)-specific ribonuclease (PARN) polypeptides using fluorescence titrations. It has also been used in crystallization along with gemin5 fragment (G5N) and DM15 region of human La-related 15 protein 1 ( LARP1).
7-Methylguanosine 5′-triphosphate (m7GTP) is use to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP may be used to create affinity media for capture and purification of molecules such as eukaryotic initiation factor eIF4E.
Biochem/physiol Actions
7-Methylguanosine 5′-triphosphate (m7GTP) inhibits in vitro protein synthesis by binding to translation initiation complexes. m7GTP is useful to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP has a high affinity for eukaryotic initiation factor eIF4E and may be used to create affinity media for their capture and purification.

Specifications

General

UNSPSC Code	41106305
PubChem Substance ID	24897079
NACRES	NA.51
Web Name Suffix Override	≥85% (HPLC), natural (inorganic), powder
MDL number	MFCD00063376
SMILES string	[Na+].C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3N=C(N)NC([O-])c13
InChI	1S/C11H20N5O14P3.Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22;/h3-4,6-7,9-10,17-18H,2H2,1H3,(H,23,24)(H,25,26)(H3,12,13,14)(H2,20,21,22);/q;+1/p-1/t4-,6-,7-,9?,10-;/m1./s1
InChI key	FSMRTZAMTMQMEF-OCMBMSOASA-M
biological source	natural (inorganic)
assay	≥85% (HPLC)
form	powder
solubility	water: 50 mg/mL, clear, colorless to faint yellow or tan
storage temp.	−20°C
Quality Level	200

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