Merck, ML0010-1KT, TCA Cycle Metabolite Library

Application

Reinforcing the Evidence of Mitochondrial Dysfunction in Long COVID Patients Using a Multiplatform Mass Spectrometry-Based Metabolomics Approach.: This study utilizes an advanced metabolomics approach to understand mitochondrial dysfunction in long COVID patients, highlighting the application of the TCA Cycle Metabolite Library for in-depth biological analysis (Martinez et al., 2024).

OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma.: This research explores the critical interactions in metabolic pathways, particularly the TCA cycle, affecting glioblastoma′s cellular metabolism and identifying potential therapeutic targets (Nguyen et al., 2024).

The interactions and biological pathways among metabolomics products of patients with coronary heart disease.: Demonstrates how metabolomics, including TCA cycle metabolites, can reveal complex biochemical pathways in coronary heart disease, offering insights into potential interventions (Chu et al., 2024).

Reduction in creatine metabolites in macrophages exposed to small molecule analogues of the anti-inflammatory parasitic worm product ES-62.: Investigates the impact of altered TCA cycle metabolites on macrophage biochemistry, providing a foundation for therapeutic research (Alanazi et al., 2024).

In-vivo tracking of deuterium metabolism in mouse organs using LC-MS/MS.: This study applies cutting-edge analytical techniques to trace metabolic pathways in vivo, including key TCA cycle intermediates, which could be pivotal for clinical metabolic research (Kasarla et al., 2024).

Preparation Note
All components are directly water soluble at ≥ 50 mg/ml.
Other Notes
Contains 10 mg each of TCA cycle metabolite standards packaged individually.