Merck, P5396-50G, Phosphomycin disodium salt

Name: Phosphomycin disodium salt
Brand: Merck
SKU: P5396-50G

Size:50 g, (−)-(1R, 2S)-(1, 2-Epoxypropyl)phosphonic acid, Fosfomycin, Phosphonomycin, antibacterial MurA inhibitor

Available Catalog Numbers

P5396-1G P5396-50G P5396-5G

Catalog Number: P5396-50G

Pricing

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Category

Antibiotics & Antimycotics

Pack Size50 g

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Antibiotics

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine.
Biochem/physiol Actions
Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. As a result, the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall, is inhibited.
Other Notes
1g,5g,50g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Specifications

General

UNSPSC Code	51102829
NACRES	NA.85
PubChem Substance ID	24278640
EC Number	247-409-2
Beilstein/REAXYS Number	4604425
MDL number	MFCD22741288
InChI	1S/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/q;2*+1/p-2/t2-,3+;;/m0../s1
InChI key	QZIQJIKUVJMTDG-JSTPYPERSA-L
SMILES string	[Na+].[Na+].C[C@@H]1O[C@@H]1P([O-])([O-])=O
form	powder
antibiotic activity spectrum	Gram-negative bacteria
mode of action	cell wall synthesis \| interferes
storage temp.	2-8°C
Quality Level	200

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