Merck, R0533-100MG, Rifapentine

Name: Rifapentine
Brand: Merck
SKU: R0533-100MG

Size:100 mg, 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin, Cyclopentylrifampicin, DL 473

Available Catalog Numbers

R0533-100MG R0533-25MG

Catalog Number: R0533-100MG

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Category

Antibiotics & Antimycotics

Pack Size100 mg

TagsChemistry & Biochemicals Biochemicals Antibiotics

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Chemical structure: macrolide
Application
Rifapentine is an antibiotic clinically used to treat tuberculosis. It is used in tuberculosis research.
Biochem/physiol Actions
Rifapentine is a semisynthetic derivative of rifampicin with antibacterial activity against Gram-positive and Gram-negative bacteria and against Mycobacterium tuberculosis. Rifapentine inhibits DNA-dependant RNA polymerase and prevents RNA transcription. It interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Semisynthetic derivative of rifampicin with antibacterial activity against Gram-positive and Gram-negative bacterial and against Mycobacterium tuberculosis. Rifapentine inhibits DNA-dependant RNA polymerase and prevents RNA transcription.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.

Specifications

General

UNSPSC Code	51283603
PubChem Substance ID	329823987
EC Number	262-743-9
NACRES	NA.85
SMILES string	N5(CCN(CC5)C6CCCC6)N=Cc1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\C([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O
InChI key	WDZCUPBHRAEYDL-OABFQHKQSA-N
InChI	1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23?/t24-,26+,27+,28+,33?,38-,39+,43+,47-/m0/s1
assay	≥93.5%
form	powder or crystals
antibiotic activity spectrum	Gram-negative bacteria
mode of action	enzyme \| inhibits
Quality Level	200
storage temp.	2-8°C

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