Merck, SML0889-25MG, bpV(phen)

Name: bpV(phen)
Brand: Merck
SKU: SML0889-25MG

Size:25 mg, Potassium bisperoxo(1, 10-phenanthroline)oxovanadate (V) hydrate, ≥95% V basis

Available Catalog Numbers

SML0889-25MG SML0889-5MG

Catalog Number: SML0889-25MG

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Category

Size Exclusion Resins

Pack Size25 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Biochem/physiol Actions
bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC₅₀ values for bpV(phen) are 38 nM for PTEN compared to 343 nM for PTPβ and 920 nM for PTP-1β. bpV(phen) has anti-inflammatory effects in oxidative stress including inhibitory effects on oxidative stress-induced cardiomyocyte injury that may be partially modulated by the action of ROS on PTEN. It may also be involved in differentiation.
bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.
bpV(phen) (potassium bisperoxo(bipyridine)oxovanadate) shows protective effect against disease progression in leishmaniasis by mediating NO-dependent microbicidal action.
Other Notes
Light Sensitive

Specifications

General

NACRES	NA.77
UNSPSC Code	12352200
InChI	1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;21-2;;/h1-8H;;21-2H;;/q;+1;;;;
InChI key	MQPXOTNOFVCXDA-UHFFFAOYSA-N
SMILES string	O=[V]123([N]4=CC=CC5=C4C6=C(C=CC=[N]62)C=C5)(OO3)OO1.[K]
assay	≥95% V basis
form	powder
storage condition	protect from light
color	faintly yellow to dark yellow
solubility	H2O: 20 mg/mL, clear
storage temp.	−20°C
Quality Level	100

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