Merck, SML1923-25MG, A-395 hydrochloride

Name: A-395 hydrochloride
Brand: Merck
SKU: SML1923-25MG

Size:25 mg, (3R, 4S)-1-(7-Fluoro-2, 3-dihydro-1H-inden-1-yl)-4-{4-[4-(methanesulfonyl)piperazin-1-yl]phenyl}-N, N-dimethylpyrrolidin-3-amine hydrochloride, ≥98% (HPLC)

Available Catalog Numbers

SML1923-25MG SML1923-5MG

Catalog Number: SML1923-25MG

Pricing

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Category

Size Exclusion Resins

Pack Size25 mg

TagsProtein Biology Bioactive Small Molecules Structural Genomics Consortium

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Biochem/physiol Actions
A-395 is a potent and selective chemical probe for the polycomb protein EED (embryonic ectoderm development), an essential component of Polycomb repressive complex 2 (PRC2), involved in transcriptional repression through methylation of histone H3K27. A-395 has been found to bind to EED in vitro with a Ki value of 0.4 nM, inhibit the PRC2 complex with an IC50 value 34 nM for methylation of H3K27, and have >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In RD rhabdoid tumor cell line A-395 inhibited the PRC2 complex with an IC50 value of 90 nM, inhibiting the formation of H3K27me3. For characterization details of A-395, please visit the A-395 probe summary on the Structural Genomics Consortium (SGC) website.

A-395N is the negative control for the active enantiomer, A-395. A-395N is available from Sigma. To learn more about and purchase A-395N, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Potent and selective chemical probe for EED
Features and Benefits
A-395 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
MDL number	MFCD31563589
InChI	1S/C26H35FN4O2S/c1-28(2)25-18-30(24-12-9-20-5-4-6-23(27)26(20)24)17-22(25)19-7-10-21(11-8-19)29-13-15-31(16-14-29)34(3,32)33/h4-8,10-11,22,24-25H,9,12-18H2,1-3H3/t22-,24?,25+/m1/s1
InChI key	REVJNSVNICWODC-KIDMSAQOSA-N
SMILES string	FC1=CC=CC2=C1C(N3C[C@H](C(C=C4)=CC=C4N5CCN(S(C)(=O)=O)CC5)[C@@H](N(C)C)C3)CC2
assay	≥98% (HPLC)
form	powder
storage condition	desiccated
color	white to light brown
solubility	H2O: 10 mg/mL, clear
storage temp.	2-8°C
Quality Level	100

Ordering

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