Merck, SML3795-25MG, BAY-3827

Name: BAY-3827
Brand: Merck
SKU: SML3795-25MG

Size:25 mg, AMPK inhibitor BAY3827, BAY 3827, N-[5-(3, 5-Dicyano-1, 2, 6-trimethyl-1, 4-dihydropyridin-4-yl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethylbenzamide, N-[5-(3, 5-Dicyano-1, 4-dihydro-1, 2, 6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethylbenzamide, ≥98% (HPLC)

Available Catalog Numbers

SML3795-25MG SML3795-5MG

Catalog Number: SML3795-25MG

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Category

Phosphatase Inhibitors

Pack Size25 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Biochem/physiol Actions
BAY-3827 is a selective and potent inhibitor of AMPK (AMP-activated protein kinase) and RSK1 (ribosomal 6 kinase 1) that exhibit strong anti-proliferative activity in androgen-dependent prostate cancer cell lines. BAY-3827 strongly down-regulates lipase E (LIPE), cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B), serine-threonine kinase AKT3 and carnitine palmitoyl-transferase 1 (CPT1) family expression levels and impairs lipid flux.
Selective and potent inhibitor of AMPK and RSK1 that exhibit strong anti-proliferative activity in androgen-dependent prostate cancer cell lines

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
Web Name Suffix Override	≥98% (HPLC), AMPK (AMP-activated protein kinase) inhibitor, powder
InChI key	OZFFKOSQNBBYCA-UHFFFAOYSA-N
SMILES string	N#CC1=C(N(C(C)=C(C#N)C1C2=CC3=C(NN=C3NC(C4=C(C=CC=C4)CC)=O)C(C)=C2F)C)C
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C
Quality Level	100

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