Merck, T1783-100MG, Tobramycin sulfate salt

Name: Tobramycin sulfate salt
Brand: Merck
SKU: T1783-100MG

Size:100 mg, Nebramycin Factor 6 sulfate, aminoglycoside antibiotic

Available Catalog Numbers

T1783-100MG T1783-500MG

Catalog Number: T1783-100MG

Pricing

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Category

Antibiotics & Antimycotics

Pack Size100 mg

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Antibiotics

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Chemical structure: aminoglycoside
Application
Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections. Product T1783 has been used to study antibiotic resistance.
Biochem/physiol Actions
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding. Tobramycin binds to an RNA aptamer, which is structurally similar to the A site of 16S rRNA.
Tobramycin sulfate is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
Packaging
100MG,500MG
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.
Disclaimer
Hygroscopic

Specifications

General

NACRES	NA.85
PubChem Substance ID	329826686
UNSPSC Code	51281677
MDL number	MFCD00133864
InChI key	ZEUUPKVZFKBXPW-TWDWGCDDSA-N
SMILES string	OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
InChI	1S/C18H37N5O9.H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1
biological source	Streptomyces tenebrarius
form	powder
potency	634-739 μg per mg
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.)
color	white to off-white
solubility	H2O: soluble 50 mg/mL
antibiotic activity spectrum	Gram-negative bacteria
mode of action	protein synthesis \| interferes
storage temp.	2-8°C
Quality Level	200

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