Proteintech, 65138-1-Ig, Anti-Mouse NK1.1 (CD161) (PK136)

65138-1-Ig targets NK1.1 (CD161) in FC applications and shows reactivity with Mouse samples.
Tested Applications
Positive FC detected in: C57BL/6 mouse splenocytes
Recommended dilution
Flow Cytometry (FC): FC : 0.5 ug per 10^6 cells in 100 μl suspension
Background Information
NK1.1 (CD161), also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).