Proteintech, 98221-1-RR, Anti-Human CCL20/MIP-3 alpha Rabbit Recombinant Antibody

98221-1-RR targets CCL20/MIP-3 alpha in FC (Intra) applications and shows reactivity with human samples.
Tested Applications
Positive FC (Intra) detected in: PMA, LPS and Brefeldin A treated THP-1 cells
Recommended dilution
Flow Cytometry (FC) (INTRA): FC (INTRA) : 0.25 ug per 10^6 cells in 100 μl suspension
Background Information
CCL20, also known as macrophage infiltrating factor protein 3α, is a C-C chemokine that specifically binds to the receptor CCR6. CCL20 is produced in various tissues and by a wide range of immune cells, including neutrophils, natural killer cells, T-helper type 17 (Th17) cells, B cells, and various antigen-presenting cells, such as dendritic cells (DCs), Langerhans cells, and macrophages. Increased expression of CCL20 is likely involved in the increased recruitment of dendritic cells observed in fibroinflammatory diseases such as chronic obstructive pulmonary disease (COPD). CCL20 expression is increased by the proinflammatory cytokine IL-1 beta.