Proteintech, 98674-2-RR, Anti-Human ADAM17 Rabbit Recombinant Antibody

98674-2-RR targets ADAM17 in FC applications and shows reactivity with human samples.
Tested Applications
Positive FC detected in: human PBMCs
Recommended dilution
Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension
Background Information
The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor (PMID:18238782). ADAM17 mediates the release of pro-inflammatory cytokines and modulates cell signaling pathways involved in tumor progression and metastasis (PMID:17438092).