Thermo Fisher, 27-1822-11, 2'-OMe-PAC-A Phosphoramidite, standard grade, 28-400 finish bottle

Quantity: 1 g
Unit Size: Each
2'-OMe-PAC-A CEP is a phosphoramidite containing 5' DMT and the nucleoside adenosine (A) with 2'-O-methyl protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methyl (OMe) oligo modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The 'standard grade' marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 30-mL amber bottle with a 28-400 finish neck style, which is compatible with most MerMade synthesizers. Features:• Full chemical name: 5'-O-(4,4'-Dimethoxytrityl)-N^6-phenoxyacetyl-2'-O-methyl-adenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite• Molecular formula: C_49H_56N_7O_9P• Base: A• Base Protection: PAC• Formula weight: 918.0 g/mol• CAS number: 128219-82-9• HPLC purity: ≥98.0%• ^31P NMR purity: ≥98.0%