Thermo Fisher, A65439, POROS™ CaptureSelect™ C1-InhXL Affinity Resin

Quantity: 250 mL
Unit Size: Each
Features of POROS CaptureSelect C1-InhXL Affinity Resin include:
• Efficient purification of C1 esterase inhibitor with high yield
• Mild pH elution condition to retain activity
• High binding capacity at high flow rates
• Excellent scalability
• Non-animal derivedFree of animal componentsCaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a 12 to 15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in the yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free).Main characteristics
• Resin:cross-linked poly(styrene-divinylbenzene) POROS beads
• Average particle size:50 μm
• Ligand:single-domain [VHH] antibody fragment
• Binding capacity:20–25 g C1-Inhibitor/L resin
• Elution conditions:50 mM sodium acetate, 1.0 M MgCl_2, pH 5.0
• Regeneration conditions:acidic stripping condition with 0.5 M acetic acid, pH 2
• Mechanical resistance:100 bar (1450 psi, 10 MPa)
• Formulation buffer:18% (v/v) ethanol