Thermo Fisher, B21459.14, Glybenzcyclamide, 99%

Name: Glybenzcyclamide, 99%
Brand: Thermo Fisher
SKU: B21459.14

Quantity: 25 g, Unit Size: Each, Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 M). This Thermo Scientific Chemicals

Catalog Number: B21459.14

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Category

Cell-Free Protein Expression Kits

Pack Size25 g

TagsChemicals Organic compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

CollectionsThermo Fisher Chemicals Collection — Analytical Solvents, Reagents & CoAs Thermo Fisher Clinical Analyzers & Instruments for Diagnostic Labs Thermo Fisher General Lab Supplies for Daily Workflows — Nalgene, Nunc, Samco & Matrix

Description

Quantity: 25 g
Unit Size: Each
ApplicationsGlyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 μM).SolubilitySoluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.NotesStore in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Specifications

General

CAS	10238-21-8
ChEBI	CHEBI:5441
Chemical Name or Material	Glybenzcyclamide
EINECS Number	233-570-6
Formula Weight	494.01
IUPAC Name	5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
InChI Key	ZNNLBTZKUZBEKO-UHFFFAOYSA-N
MDL Number	MFCD00056625
Melting Point	171°C to 174°C
Molecular Formula	C23H28ClN3O5S
PubChem CID	3488
Recommended Storage	Keep cold
SMILES	COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
Solubility Information	Soluble in ethanol (5mg/mL),DMSO (25mg/mL),chloroform (1:36),methanol (1:250),and DMF. Insoluble in water.
Synonym	glynase
TSCA	No
Molecular Weight (g/mol)	494.003
Percent Purity	99%
Quantity	25 g
Unit Size	Each

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Thermo Fisher, B21459.14, Glybenzcyclamide, 99%

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