Thermo Fisher, R261605, Beta Lactam Disk

Name: Beta Lactam Disk
Brand: Thermo Fisher
SKU: R261605

Quantity: 25 Disks/Vial, Unit Size: Each, Detect beta lactamase production by certain strains of Haemophilus sp., Neisseria gonorrhoeae, and Staphylococcus sp. using a reagent-impregnated Thermo Scientific™ Remel™ Beta Lactam™ Disk. Several acidometric methods using phenol red as an indicator and penicillin as a substrate have been published^12, 1-3. In 1972, O'Callaghan et al. described a beta lactamase procedure using chromogenic cephalosporin as a substrate^12. Cresol red and bromocresol purp

Catalog Number: R261605

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Category

Glucose Test Kits

TagsResearch and Clinical Diagnostic Tests and Controls Other Controls and Reagents Immunoassay Testing

CollectionsThermo Fisher Clinical Analyzers & Instruments for Diagnostic Labs Thermo Fisher General Lab Supplies for Daily Workflows — Nalgene, Nunc, Samco & Matrix Thermo Fisher Laboratory Kits for qPCR, ELISA, Transfection & NGS

Description

Quantity: 25 Disks/Vial
Unit Size: Each
Certain gram-positive and gram-negative bacteria produce an important class of enzymes called beta-lactamases, which may be mediated by genes on plasmids or chromosomes. These enzymes confer resistance to many penicillin antibiotics by cleaving the beta-lactam ring of penicillin and cephalosporin antibiotics, resulting in inactivation of these drugs. They are capable of inactivating “penicillinase-labile-penicillins”, such as amoxicillin, ampicillin, penicillin, carbenicillin, mezlocillin, and piperacillin. β-lactamases thus play a key role in bacterial resistance to beta-lactam agents, and detection of their presence can provide useful information^5.
• Ready to Use:Reagent impregnated disk
• Rapid Test:Results are obtained within 30 minutes. Reaction time for the positive test is 1-10 minutes.
• Easy-to-identify:Positive test:Color change from blue to yellow indicates the production of beta lactamase.Negative test:No color change indicates no beta lactamase production.Beta lactamase production by certain strains of Neisseria gonorrhoeae, Haemophilus influenzae, and Staphylococcus aureus has been demonstrated^6-13. Several clinical tests have been developed for the detection of beta lactamases.The Beta Lactam Disk is impregnated with benzylpenicillin which contains a beta lactam ring. When the beta lactamase enzyme is produced by an organism, the beta lactam ring of benzylpenicillin is hydrolyzed to form penicilloic acid. This cleavage of the beta lactam ring inactivates the antibiotic. The resulting fall in pH is indicated by the bromocresol purple indicator changing from purple to yellow.Not all products are available for sale in all territories. Please inquire.Remel™ and Oxoid™ products are now part of the Thermo Scientific brand.

Specifications

General

Description	Beta Lactam™ Reagent Disk
Format	Vial
Quantity	25 Disks/Vial
Detectable Analytes	beta-lactamase (Haemophilus species, N. gonorrhoeae,Staphylococci)
Unit Size	Each

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