Cytiva
Adjustable Oligo Column
SKU · 18110760
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Discover how Cytiva makes oligonucleotide synthesis and purification simple and reliable, whether you’re working at the research bench or producing at scale. With advanced solutions for both DNA and RNA synthesis, as well as efficient purification workflows, Cytiva helps you achieve high-purity results you can trust—every time.
Our technologies are built to support you through every step of the oligo manufacturing process, offering the purity, scalability, and compliance needed for today’s scientific and industrial demands. Chosen by labs and manufacturers around the world, Cytiva’s products give you the flexibility and performance to drive breakthroughs in diagnostics, therapeutics, and genomics.
To support every stage of your oligonucleotide workflow, Cytiva offers a curated selection of specialized products tailored for DNA and RNA synthesis, purification, and process scale-up. Explore the unique features and application focus of each product type to find the optimal solution for your research or manufacturing needs.
Chromatography Resins & Media
Core parameters: Particle sizes from 15–90 μm; high binding capacity; scalable from lab to production.
Key advantages: Superior purity, high throughput, GMP compliance, easy scale-up.
Typical applications: Ion exchange and reversed-phase purification of DNA/RNA oligonucleotides for research, clinical, and GMP production.
Oligonucleotide Synthesis Columns
Core parameters: Optimized flow rates; robust construction; broad compatibility with synthesizers.
Key advantages: Consistent synthesis efficiency, minimized carryover, high reproducibility.
Typical applications: Automated DNA/RNA synthesis in laboratories and pilot production.
Prepacked Columns
Core parameters: Ready-to-use; filled with industry-leading chromatography resins; available in various sizes.
Key advantages: Convenient setup, reduced validation time, reproducible results, scalable for process development and manufacturing.
Typical applications: Fast purification of oligonucleotides in research, process development, and GMP environments.
Purification Reagents & Consumables
Core parameters: High-purity reagents; compatible with leading synthesis and purification platforms.
Key advantages: Reliable performance, reduced contaminants, streamlined workflows.
Typical applications: Oligonucleotide desalting, deprotection, and polishing steps for both laboratory and industrial production.
No matter your scale or application, Cytiva’s oligonucleotide synthesis and purification solutions help ensure efficiency, quality, and compliance at every step.
Selecting the right partner is critical when your goals are efficiency, compliance, and consistent oligo quality. Cytiva stands out for its relentless focus on scientific innovation and operational excellence in oligonucleotide synthesis and purification.
Our proprietary high-capacity chromatography media and precision purification technologies are the result of continuous research and close collaboration with leading scientists. These innovations enable not just higher yields and purity, but also reliable performance across automated and scalable production environments.
As a global industry leader, Cytiva is recognized for its commitment to quality and regulatory compliance. All solutions meet stringent GMP and ISO standards, supporting seamless transitions from development to commercial manufacturing. Our established global supply chain, responsive technical support, and customer-centric service ensure you have a dependable partner at every stage.
With Cytiva, you gain more than advanced products—you access a network of expertise, industry trust, and ongoing support to empower your scientific breakthroughs and business growth.
Selecting the right chromatography media, synthesis column, or purification reagent ensures optimal yield, purity, and cost efficiency. The table below matches common application scenarios with Cytiva’s validated SKUs, guiding you through flexible options suitable for lab-scale research up to industrial GMP production.
Product Selection Table
| Application Scenario | Recommended Product Type | Key Parameters | Why Choose This Product |
|---|---|---|---|
| Lab-scale DNA/RNA synthesis | Synthesis Columns | Stainless steel, optimized flow, 1–5 mL | Excellent reproducibility for research and pilot batches |
| Lab-scale oligonucleotide purification | MicroSpin G‑50 DNA Grade Column | Sephadex G‑50 resin, 12–50 µL volume | Fast desalting and dye removal post-synthesis |
| Medium-scale purification | HiPrep 26/10 Desalting Column | Sephadex G‑25 resin, 53 mL bed | Convenient buffer exchange ≥15 mL, ÄKTA compatible |
| Large-scale/GMP production | Capto Q Chromatography Resin | Strong anion exchange, 90 µm particle | High binding capacity, scalable, GMP-ready |
Classic SKUs for Key Oligonucleotide Workflows
| SKU | Product Name | Application Scale | Key Specs |
|---|---|---|---|
| 27‑5330‑02 | MicroSpin G‑50 DNA Grade Column | Lab-scale purification | Sephadex G‑50, 12–50 µL bed volume |
| 17‑5087‑01 | HiPrep 26/10 Desalting Column | Medium-scale purification | 53 mL Sephadex G‑25 bed, up to 15 mL sample |
| 17‑5316‑10 | Capto Q Chromatography Resin (25 mL) | Large-scale production | 90 µm particles, strong ion exchange |
| 17‑5055‑01 | HiTrap DEAE Sepharose FF, 1 mL prepacked | Pilot/medium-scale work | Weak anion exchanger, 5 mL column volume |
By matching product characteristics to your synthesis scale, desired purity, and workflow compatibility, Cytiva lets you quickly build a customized solution—from micro‑volume research to full‑scale GMP manufacturing. Next, explore our FAQ section for practical guidance and expert insights.
1. How can I improve the purity of synthesized oligonucleotides?
Use optimized purification methods like size-exclusion (MicroSpin G‑50 columns) or ion-exchange chromatography (Capto Q resin). High-quality reagents and proper buffers further enhance purity.
2. What technical support does Cytiva offer for oligonucleotide workflows?
Cytiva offers protocols, troubleshooting guides, and expert support for product selection, process optimization, and scale-up to GMP production.
3. What is the maximum oligonucleotide length supported by Cytiva purification products?
Most Cytiva columns and resins handle oligos up to 200 nucleotides or more. Check the product datasheet for exact compatibility.
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