Description
Key facts
Detection method:Colorimetric,
Sample types:Citrate plasma, Heparin Plasma, Serum,
Reacts with:Human,
Assay type:Sandwich (qualitative),
Assay Platform:Microplate
Product details:
ab108778 Toxoplasma gondii IgM Human ELISA Kit is intended for the qualitative determination of IgM class antibodies against Toxoplasma gondii in human serum or plasma (citrate).
Toxoplasma gondii is a small intracellular parasite, whose live cycle has a sexual and an asexual phase. Sexual development is restricted to the intestinal cells of (probably exclusively) cats; the oocysts formed are excreted and due to their resistant cell walls they may be infectious under advantageous circumstances for at least 1 year. Animals and man are intermediate hosts for the asexual proliferation of T. gondii: the ingested parasites will proliferate explosively within the host cells lysing them eventually. They disseminate throughout the body via circulation and lymphatic system and may infect any cell type. In muscle and brain cells cysts are formed which are spheroidal and about 5-100 μm in diameter. Cysts are virtually immortal in the intermediate host.
Toxoplasma gondii is the most common parasite in humans, but its abundance (7-80%) is highly dependent on the geographic area, the socio-economic status and the nutritional customs. Infection only rarely causes toxoplasmosis and usually clinical symptoms are absent, but may produce severe problems in immunosuppressed persons and fetus.
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Toxoplasma gondii IgM is an immunoglobulin that plays a significant role in the immune response against the parasite Toxoplasma gondii. This IgM also known as 'anti-Toxoplasma IgM' is specifically expressed during the acute phase of infection. It is part of the body's effort to fight off the Toxoplasma a protozoan parasite known for causing infections in a wide range of hosts including humans. The IgM antibodies are large molecules with a mass of approximately 970 kDa primarily found in the blood circulation during early infection stages.
Biological function summary
Anti-Toxoplasma gondii IgM signals the immune system that Toxoplasma has invaded the host. The emergence of this antibody typically occurs in the initial phases of toxoplasmosis indicating a recent infection. These antibodies do not form part of any complex but have a direct role in identifying pathogens so that other immune components can target them efficiently. Successful detection of anti-Toxoplasma IgM contributes to the containment of the infection and prevents further systemic damage.
Pathways
The anti-Toxoplasma IgM is an important element in the immune response pathway known as the humoral immune response. This pathway involves the production of antibodies that act to neutralize extracellular pathogens. The anti-Toxoplasma IgM works closely with other antibodies such as IgG to facilitate pathogen neutralization and removal by phagocytes. While the IgM indicates recent infection IgG plays an important role in longer-term immunity against Toxoplasma gondii.
Anti-Toxoplasma IgM is especially relevant in the context of acute toxoplasmosis and congenital toxoplasmosis. The testing for these antibodies often conducted via an ELISA TORCH test aids in diagnosing these conditions. In congenital toxoplasmosis the presence of anti-Toxoplasma IgM in newborns suggests an infection acquired in the womb. The antibody connections in these diseases are mostly with anti-Toxoplasma IgG which helps to determine the chronicity of the infection.
