Description
Key facts
CAS number:301836-43-1,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:398.4 Da,
Molecular formula:C23H18N4O3,
PubChem:6419753,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:CK1 Inhibitor,
Biological description:Selective cell-permeable inhibitor of casein kinase 1 (CK1) . (IC50 values are 0.3 (CK1), 0.5 (ALK5), 9.1 (PKd1) and 5.8 μM (p38αMAPK)). Displays selectivity over many other protein kinases.,
Canonical smiles:C1COC2=C(O1)C=CC(=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5,
InChi:InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27),
InChiKey:DPDZHVCKYBCJHW-UHFFFAOYSA-N,
IUPAC Name:4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
P38 also known as MAPK14 weighs approximately 43 kDa and is a member of the mitogen-activated protein kinase family. It is expressed in many tissues with high levels in the heart and skeletal muscle. p38 acts mechanically by phosphorylating various substrates involved in cellular responses to stress and inflammation. Protein Kinase C mu/PKD also referred to as PKD1 is part of the protein kinase D family. It has a mass of around 115 kDa and functions by relaying signaling pathways important for maintaining cellular activities. TGF beta Receptor I also known as activin receptor-like kinase 5 (ALK5) is a serine/threonine kinase of about 53 kDa found in various tissues. CLK1 or CDC-like kinase 1 has a mass of approximately 52 kDa and plays roles in pre-mRNA splicing and regulation.
Biological function summary
All these proteins play key roles in cellular communication and response modulation. p38 adjusts the cellular response to external stress signals and inflammation and it often forms part of larger signaling complexes. PKC mu/PKD regulates signal transduction pathways involved in cell proliferation and migration. TGF beta Receptor I mediates signaling for TGF-beta regulating cell growth and differentiation. CLK1 influences aspect of RNA splicing affecting gene expression and cellular metabolism.
Pathways
P38 MAPK signaling includes phosphorylation chains impacting cellular inflammatory response while closely interacting with proteins like MKK3 and MKK6. PKC mu/PKD signaling is integral to the DAG-activated pathway where it associates with proteins like Rac1. TGF beta Receptor I is critical for the TGF-beta signaling pathway interacting with SMAD proteins to transduce signals. CLK1 affects the CLK1 signaling pathway influencing RNA splicing through interactions with SR proteins.
P38 links to conditions such as inflammatory diseases and cancer. It connects with cytokine signaling proteins impacting disease progression. PKC mu/PKD associates with cancer and cardiovascular diseases through its role in cellular proliferation. TGF beta Receptor I's dysfunction correlates with fibrotic diseases through interactions with ECM-modifying proteins. CLK1 relates to neurological disorders influencing proteins involved in RNA processing such as ASF/SF2.
