Description
Key facts
CAS number:364-98-7,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:230.67 Da,
Molecular formula:C8H7ClN2O2S,
PubChem:3019,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:Diazoxide,
Biological description:Selective KIR6.x (KATP) activator; antihypertensive.,
Canonical smiles:CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl,
InChi:InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11),
InChiKey:GDLBFKVLRPITMI-UHFFFAOYSA-N,
IUPAC Name:7-chloro-3-methyl-4H-1λ6,2,4-benzothiadiazine 1,1-dioxide
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYP2D6 also known as Cytochrome P450 2D6 is a member of the cytochrome P450 superfamily of enzymes with an approximate mass of 55 kDa. This enzyme is mainly expressed in the liver though its presence is also detected in other tissues such as the brain. It plays an important role in the metabolism of xenobiotics including drugs by catalyzing their oxidation. Notably CYP2D6 demonstrates significant genetic polymorphism influencing individual drug responses and metabolism efficiency.
Biological function summary
CYP2D6 impacts various metabolic processes by serving as an enzyme that metabolizes approximately 25% of clinical drugs including antidepressants and antipsychotics. It forms part of the large P450 enzyme family but operates dynamically through its metabolic functions rather than as a consistent participant in stable complexes. In addition to drug metabolism CYP2D6 participates in the synthesis of cholesterol steroids and other lipids.
Pathways
CYP2D6 interacts with the drug metabolism pathway particularly affecting the metabolic fate of numerous pharmaceuticals and endogenous substrates. This enzyme contributes to the cytochrome P450 pathway which is pivotal in detoxifying chemicals and metabolizing various bioactive molecules. CYP2D6 functions alongside related cytochrome enzymes like CYP3A4 affecting the metabolism of overlapping substrates.
CYP2D6 has associations with varied pharmacogenomic responses affecting treatment for diseases such as depression and schizophrenia. People with different CYP2D6 polymorphisms may experience altered drug efficacy and side effect profiles impacting treatment outcomes. Mutations or variations in CYP2D6 activity relate to other enzymes like CYP2C19 and can modulate the risk or management of conditions linked with complex drug regimens.
