Description
Key facts
CAS number:1120-02-1,
Form:SolidSee storage information,
Molecular weight:392.5 Da,
Molecular formula:C21H46BrN,
PubChem:70708,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mM (with warming),
Biochemical name:Trimethyloctadecylammonium bromide,
Biological description:Cell-permeable dynamin I and dynamin II inhibitor (IC50 values are 1.9 and 4.4 μM for inhibition of dynamin I and II GTPase, respectively). Targets the pleckstrin homology (PH) (lipid binding) domain. Competitive with phospholipid and non-competitive with GTP. Inhibits receptor-mediated endocytosis (IC50 = 6.7 μM). Inhibits cancer cell growth.,
Canonical smiles:CCCCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-],
InChi:InChI=1S/C21H46N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(2,3)4;/h5-21H2,1-4H3;1H/q+1;/p-1,
InChiKey:SZEMGTQCPRNXEG-UHFFFAOYSA-M,
IUPAC Name:trimethyl(octadecyl)azanium;bromide
Product details:
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. OcTMAB™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Dynamin 1 also known as DNM1 is a GTPase with a molecular mass of approximately 96 kDa. It plays a mechanical role in membrane fission during endocytosis. Dynamin 1 is primarily expressed in neuronal tissues where it participates in the formation and release of synaptic vesicles. Its ability to hydrolyze GTP gives it the mechanical force needed to constrict and sever membranes which is vital for efficient synaptic vesicle recycling in neurons.
Biological function summary
Dynamin 1 helps regulate synaptic transmission by controlling vesicular traffic in neurons. As part of a larger protein complex it interacts with various proteins to mediate endocytosis specifically in presynaptic nerve terminals. These interactions ensure that synaptic vesicles are recycled rapidly allowing neurons to maintain communication across synapses. Disruptions in dynamin 1 function can impair synaptic vesicle recycling affecting neurotransmission efficiency.
Pathways
Dynamin 1 is essential in the clathrin-mediated endocytic pathway. This pathway is a major route for internalizing synaptic vesicles and involves cooperation with other proteins such as clathrin and adaptor proteins. Additionally dynamin 1 participates in the actin cytoskeleton dynamics linking it with actin-associated proteins. These pathways highlight its contributions to maintaining synaptic vesicle endocytosis and neurite outgrowth processes.
Alterations in dynamin 1 function are linked to neurological disorders including epilepsy and Huntington's disease. In epilepsy improper functioning of dynamin 1 disrupts synaptic vesicle recycling leading to imbalances in neurotransmitter release. Connections exist between dynamin 1 and huntingtin where their interactions in vesicular trafficking are important for neuronal stability. Malfunctions in these processes often result in neurodegenerative symptoms emphasizing dynamin 1's involvement in sustaining neural health.
