Description
Key facts
Applications:FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.
Product details:
The Dynamin Inhibitors Toolbox (ab120468) is a unique collection of small molecule, potent, and cell permeable dynamin inhibitors, enabling characterization of dynamin and endocytosis. The inhibitors have different mechanisms of action, target different domains of dynamin, and are based on differing chemical scaffolds.
Negative controls for each chemical series are included.
The Toolbox contains 1mg of each of the following: MiTMAB™ (ab120466), OcTMAB™ (ab120467), Pro-Mystyric Acid (ab120476), Dynole-34-2™ (ab120463) and Dynole-31-2™ (ab120464)
MiTMAB
chemical series collection
Contains MiTMAB
ab120466
), OcTMAB
ab120467
) and Pro-Myristic Acid (ab120476). OcTMAB
and MiTMAB
target dynamin at the lipid binding (PH) domain and inhibit dynamin and endocytosis in enzymatic and cell based assays. They are based on the same chemical scaffold.
Pro-Myristic acid is an in vitro inhibitor of dynamin. Although cell permeable, it is rapidly broken down by cellular esterases to release intracellular myristic acid, which is not a dynamin inhibitor. It can therefore be used as a negative control in cell-based studies.
Dynole
chemical series collection
Contains dynamin inhibitor Dynole-34-2
ab120463
) and negative control Dynole-31
ab120464
) from the Dynole chemical series. Dynole-34-2
targets dynamin at the GTPase Allosteric Site (GAS) domain and inhibits dynamin and endocytosis in enzymatic and cell based assays. The inhibitor and negative control are based on the same chemical scaffold.
PH lipid binding site
MiTMAB™ -
Cell-permeable dynamin I and dynamin II inhibitor
PH lipid binding site
OcTMAB™ -
Cell permeable dynamin I and dynamin II inhibitor
PH lipid binding site
Pro-Myristic Acid -
Negative control for MiTMAB™ and OcTMAB™
GTPase Allosteric Site
Dynole-34-2™ -
Potent dynamin I and dynamin II inhibitor
GTPase Allosteric Site
Dynole-31-2™ -
Negative control for Dynole 34-2™
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Dynole-34-2™, Dynole-31-2™, MiTMAB™ and OcTMAB™ are trademarks of Children's Medical Research Institute and Newcastle Innovation Ltd.
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C
