Description
Key facts
CAS number:1986-47-6,
Purity:>97%,
Form:SolidSee storage information,
Molecular weight:169.65 Da,
Molecular formula:C9H12ClN,
PubChem:2723716,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:Tranylcypromine hydrochloride,
Biological description:Irreversible monoamine oxidase (MAO) inhibitor. Increases serotonergic, noradrenergic activity and augments dopamine transmission. Additionally inhibits LSD1 (BHC110), inhibiting histone demethylation (IC50 = >50 μM). Anticonvulsant and antidepressant.,
Canonical smiles:C1C(C1N)C2=CC=CC=C2.Cl,
Isomeric smiles:C1[C@H]([C@@H]1N)C2=CC=CC=C2.Cl,
InChi:InChI=1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1,
InChiKey:ZPEFMSTTZXJOTM-OULXEKPRSA-N,
IUPAC Name:(1R,2S)-2-phenylcyclopropan-1-amine;hydrochloride
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Monoamine oxidase A and B (MAO-A and MAO-B) are enzymes that play a role in the oxidative deamination of monoamines with alternate names such as MAO-A and MAO-B. They have a mass of approximately 60 kDa and are found in various tissues including the brain liver and intestines. These enzymes contribute to the metabolic breakdown of neurotransmitters such as serotonin dopamine and norepinephrine. TAAR1 also known as Trace amine-associated receptor 1 is a receptor expressed in the central nervous system and peripheral tissues responding to endogenous trace amines. KDM1 also called LSD1 (Lysine-specific demethylase 1) and LSD2 or AOF1 are enzymes involved in histone demethylation important for chromatin remodeling and gene expression regulation. Both LSD1 and LSD2 are expressed in multiple tissues including the brain and reproductive organs.
Biological function summary
Monoamine oxidases and TAAR1 are important for the modulation of neurotransmitter systems and maintain amine homeostasis. These proteins lack complex formation impacting neurotransmitter levels differently. KDM1/LSD1 and LSD2/AOF1 function to remove methyl groups from lysine residues on histones affecting gene expression patterns thereby modifying transcriptional programs. In their role in chromatin demethylation they contribute to the regulation of several essential genes across various tissues.
Pathways
Monoamine oxidases play a critical part in the catabolic pathways related to neurotransmitter degradation such as the serotonin and dopamine pathways. In these pathways they have intersections with other proteins like the catechol-O-methyltransferase (COMT). TAAR1 links to the signal transduction pathways that modulate intracellular cAMP levels. KDM1/LSD1 and LSD2 take part in the histone modification pathway which holds importance in transcription regulation and has connections to proteins like histone deacetylases (HDACs).
Monoamine oxidases link to conditions like depression and Parkinson's disease with their inhibition leading to increased availability of neurotransmitters. MAO inhibitors (MAOIs) are therapeutic agents for these disorders showing the importance of these enzymes. TAAR1 has associations with schizophrenia and mood disorders interacting with dopamine receptor signaling. KDM1/LSD1 and LSD2 hold connections to oncogenesis in certain cancers by affecting gene expression implicating interactions with other epigenetic regulators in these disease states.
