Key facts
CAS number:51372-29-3,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:430.5 Da,
Molecular formula:C25H34O6,
PubChem:40000,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 50 mM,
Biochemical name:Dexbudesonide,
Biological description:Glucocorticoid receptor binding affinity, stimulates transcription of target gene. Highly potent IL-4 and IL-5 release inhibitor (IC50 values are 320 and 220 pM, respectively). Potent concanavalin A-induced proliferation inhibitor (IC50 = 1.3 nM). Anti-asthmatic and anti-inflammatory agent. Orally active. Active *in vivo* and *in vitro*.,
Canonical smiles:CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C,
Isomeric smiles:CCC[C@@H]1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C,
InChi:InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21+,22+,23-,24-,25+/m0/s1,
InChiKey:VOVIALXJUBGFJZ-VXKMTNQYSA-N,
IUPAC Name:(1S,2S,4R,6R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The targets listed are transcription factors and nuclear receptors such as c-Jun and various glucocorticoid and sex hormone receptors. c-Jun a component of the activator protein 1 (AP-1) complex regulates gene expression in response to various stimuli. The glucocorticoid receptor (GR) binds glucocorticoids including synthetic ones like budesonide a glucocorticoid used in anti-inflammatory treatments. GR and other hormone receptors like estrogen progesterone and androgen receptors share similar structures and are expressed across various tissues. These receptors exhibit distinct mass properties and localization influencing their role in cellular proliferation and differentiation.
Biological function summary
Transcription factors and nuclear receptors impact cellular processes by modulating gene expression. c-Jun contributes to the AP-1 complex which affects cell proliferation and survival while glucocorticoid and other hormone receptors regulate genes relevant to metabolism immune response and reproductive functions. Nuclear receptors for sex hormones typically function as dimers which can be either homodimers or heterodimers influencing their regulatory capacities. The retinoic acid receptor alpha and peroxisome proliferator-activated receptor alpha further diversify the biological impacts through specific gene activation integrating signals from retinoids and peroxisomes.
Pathways
These targets have important roles in the regulation of significant biological pathways like the MAPK/ERK pathway for c-Jun which relates to cellular responses to growth signals and the steroid hormone signaling pathway for glucocorticoid and sex hormone receptors. Interaction with proteins such as NF-kappaB FoxO and others enhances their influence on metabolism stress responses and immune regulation. Specifically the androgen receptor and glucocorticoid receptor interact with molecular chaperones to ensure proper receptor conformation and function within these pathways.
These targets play significant roles in cancer and autoimmune conditions. The estrogen receptor's aberrant signaling associates with breast cancer where c-Jun also contributes to oncogenic processes. Similarly the glucocorticoid receptor affects conditions like rheumatoid arthritis by modulating inflammatory pathways. These receptors particularly when dysregulated influence disease progression through interactions with proteins like p53 and NF-kappaB highlighting their importance in therapeutic strategies.
