Description
Key facts
CAS number:102121-60-8,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:351.4 Da,
Molecular formula:C22H25NO3,
PubChem:2126,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 50 mM,
Biochemical name:4-{[(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid,
Biological description:Selective RARα agonists (EC50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Shows anticancer effect. Active in vivo.,
Canonical smiles:CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C,
InChi:InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26),
InChiKey:SZWKGOZKRMMLAJ-UHFFFAOYSA-N,
IUPAC Name:4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Retinoic Acid Receptor gamma (RARG) Vitamin D Receptor (VDR) and Estrogen Receptor (ER) are members of the nuclear receptor superfamily acting as transcription factors regulating gene expression. Known by other names these receptors are pivotal in various physiological functions. RARG's molecular mass is approximately 54 kDa while others such as VDR weigh around 48 kDa. These receptors show diverse expression patterns; RARG is found in the skin and immune cells VDR expresses in bones and intestines and ER is notably present in breast tissue. TSH Receptor (TSH-R) operates in thyroid gland while Androgen Receptor (AR) finds expression mostly in prostate tissue. Retinoic Acid Receptor alpha (RARA) and beta (RARB) share similar functional roles with RXRA but each has unique tissue-specific patterns of expression. ROR gamma and Nrf2 also play key roles as transcriptional regulators in immune and oxidative stress responses respectively.
Biological function summary
These nuclear receptors influence major body systems by interacting with hormones or vitamins to regulate gene transcription. They form dimeric or heterodimeric complexes such as RXRA pairing with retinoic acid receptors. RARG VDR and ER modulate cell differentiation proliferation and apoptosis. TSH-R primarily regulates thyroid hormone synthesis influencing metabolism. AR mediates sexual development and reproductive functions while RORA and RARB partakes in embryonic development. ROR gamma is essential for thymopoiesis an aspect of immune defense. Nrf2 manages cellular antioxidant defense by initiating transcription of protective genes promoting cellular resilience against oxidative stress.
Pathways
These receptors integrate into critical signaling networks affecting multiple cellular processes. The retinoic acid-mediated pathway involves RARG RARA and RXRA influencing gene expression for tissue morphogenesis and homeostasis often linked with RXRA partners like PPARs. Similarly the Vitamin D pathway involves VDR impacting calcium and phosphate metabolism through interaction with proteins like calmodulin. Their involvement extends to immune response regulation and metabolic processes wherein ER components intersect with steroid biosynthesis pathways to modulate reproductive health.
The misregulation of these receptors links to various clinical conditions. RAR malfunctions can result in dermatological disorders and immune diseases. Increased or decreased activity in AR associates with prostate cancer affirming its role in tumorigenesis. RXRA in metabolic syndrome has links with lipid regulation issues when pathways malfunction. VDR's defective signaling connects to osteoporosis through impaired calcium metabolism. Nrf2's defective regulation associates with neurodegenerative diseases and cancer driven by disrupted oxidative stress responses.
