Description
Key facts
CAS number:941678-49-5,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:306.4 Da,
Molecular formula:C17H18N6,
PubChem:25126798,
Nature:Synthetic,
Solubility:Soluble in DMSO to 16 mMSoluble in ethanol to 32 mM,
Biochemical name:Ruxolitinib,
Biological description:Potent, selective ATP-competitive Janus-associated kinase 1 and 2 inhibitor (IC50 values of 3.3, 2.8 and 428 nM for JAK1, JAK2 and JAK3 respectively in vitro). Inhibits IL-6 signaling (IC50 = 281nM). Orally bioavailable.,
Canonical smiles:C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3,
Isomeric smiles:C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3,
InChi:InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1,
InChiKey:HFNKQEVNSGCOJV-OAHLLOKOSA-N,
IUPAC Name:(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
